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anses

French Agency for Food, Environmental and Occupational Health & Safety

List of toxicity reference values (TRVs) established by ANSES

The Agency entrusted TRV validation to the Expert Committee (CES) on "Health reference values ". Accordingly, toxicity reference values have already been established  for the following substances.

 

Chemical

Year

Sort of TRV

TRV

1,2 dichloroethane

(CAS 107-06-2)

2009

Carcinogen TRV

Inhalation route 

 

3,4.10-3 (mg.m-3)-1

 

2-chloroaniline

(CAS 95-51-2)

2018

Acute TRV

Oral route

73 µg.kg p.c.-1.d-1
2018

Acute TRV

Inhalation route

256 µg.m-3
2018

Subchronic TRV

Oral route

16 µg.kg p.c.-1.d-1

2018

Subchronic TRV

Inhalation route

55 µg.m-3
2018

Chronic TRV

Oral route

5 µg.kg p.c.-1.d-1
2018

Chronic TRV

Inhalation route

18 µg.m-3

2-ethoxyethanol

(CAS 110-80-5)

2009

Chronic TRV

Inhalation route

0,07 mg.m-3

3-chloroaniline

(CAS 108-42-9)

2018

Acute TRV

Oral route

11 µg.kg p.c.-1.d-1
2018

Acute TRV

Inhalation route

39 µg.m-3
2018

Subchronic TRV

Oral route

5 µg.kg p.c.-1.d-1
2018

Subchronic TRV

Inhalation route

18 µg.m-3
2018

Chronic TRV

Oral route

1 µg.kg p.c.-1.d-1
2018

Chronic TRV

Inhalation route

µg.m-3

4-chloroaniline

(CAS 106-47-8)

2018

Subchronic TRV

Oral route

5 µg.kg p.c.-1.d-1
2018

Subchronic TRV

Inhalation route

18µg.m-3
2018

Chronic TRV

Oral route

1 µg.kg p.c.-1.d-1
2018

Chronic TRV

Inhalation route

µg.m-3

4-Vinyl-1-cyclohexene

(CAS 100-40-3)

2015

Chronic TRV

Oral route

0,32 mg .kg.pc-1.d-1
2015

Chronic TRV

Inhalation route

2,7 mg.m-3
2015

Carcinogen TRV

Oral route

1,3.10-5 (µg.kg p.c.-1.d-1)-1
2015

Carcinogen TRV

Inhalation route

3,8.10-6 (µg.m-3)-1

Acrolein

(CAS 107-02-8)

2019

Acute TRV

Inhalation route

6,9 µg.m-3

Subchronic TRV

Inhalation route

0,44 µg.m-3

Chronic TRV

Inhalation route

0,15 µg.m-3

Ammonia

(CAS 7664-41-7)

2017

Acute TRV

Inhalation route

5,9 mg.m-3

Subchronic TRV

Inhalation route

0,5 mg.m-3

Chronic TRV

Inhalation route

0,5 mg.m-3

Benzene

(CAS 71-43-2)

2013

Carcinogen TRV

Inhalation route

2,6.10-5 (µg.m-3)-1

bis(2-ethylhexyl) phthalate (DEHP)

(CAS 117-81-7)

2012

Chronic TRV

Oral route

0,05 mg.kg-1.d-1

Butyl benzyl phthalate (BBP)

(CAS 85-68-7)

2008

Subchronic TRV

Oral route

0,5 mg.kg-1.d-1

Cadmium and cadmium compounds

(CAS 7440-43-9, 10108-6-2,

1306-19-0, 10124-36-4,

1306-23-6, 10325-94-7)

2017

Chronic TRV

Oral route

0,35 µg.kg-1.d-1

2012

Chronic TRV 

Inhalation route 

 

0,45 µg.m-3

2012

Carcinogen TRV

Inhalation route

 

0,3 µg.m-3

Carbon tetrachloride

(CAS 56-23-5)

2017

Carcinogen TRV

Inhalation route

0,11 mg.m-3

Chloral hydrate

(CAS 302-17-0)

2010

Chronic TRV

Oral route

28 µg.kg-1.d-1

Chloroform

(CAS 67-66-3)

2008

Chronic TRV

Inhalation route

63 µg.m-3

Cylindrospermopsin

(CAS 143 545-90-8)

2019

Subchronic TRV

Oral route

0,14 µg.kg-1.d-1

Decamethylcyclopentasiloxane

(D5)

(CAS 541-02-6)

2017

Chronic TRV

6,4 mg.m-3

Dibromoacetic acid

(CAS 631-64-1)

2010

Chronic TRV

Oral route

30 µg.kg-1.d-1

Dibutyl phthalate (DBP)

(CAS 84-74-2)

2008

Subchronic TRV

Oral route

0,002 mg.kg-1.d-1

 Diisobutylene (DIB)

(CAS 25167-70-8)

2015

Chronic TRV

Oral route

0,8 mg.kg pc-1.d-1

2015

Chronic TRV

Inhalation route

3 mg.m-3

Diisopropyl ether (DIPE)

(CAS 108-20-3)

 

2015

Chronic TRV

Oral route

4 mg.kg pc-1.d-1

2015

Chronic TRV

Inhalation route

14,5 mg.m-3

2015

Developmental TRV

Oral route

2 mg.kg pc-1.d-1

2015

Developmental TRV

Inhalation

7,2 mg.m-3

2015

Carcinogen TRV

Oral route

7,8.10-6 (µg.kg p.c.-1.d-1)-1

2015

Carcinogen TRV

Inhalation route

2,2.10-6 (µg.m-3)-1

Dichloroacetic acid

(CAS 79-43-6)

2009

Acute TRV

Oral route

260 µg.kg-1.d-1

Chronic TRV

Oral route

840 µg.kg-1.d-1

Diisobutyl phthalate (DIBP)

(CAS 84-69-5)

2017

Acute TRV (reprotoxic)

Oral route

0,002 mg.kg-1.d-1

Diisooctyl phthalate (DIOP)

(CAS 27554-26-3)

2017

Acute TRV (reprotoxic)

Oral route

0,004 mg.kg-1.d-1

Dimethyl phthalate

(CAS 131-22-3)

2015

 

No TRV

Di-n-octyl phthalate (DnOP)

(CAS 117-84-0)

2017

 

No TRV

Ethyl acetate

(CAS 141-78-9)

2015

Chronic TRV

Inhalation route

6,4 mg.m-3

Ethylbenzene

(CAS 100-41-1)

2016

Acute TRV

Inhalation route

22 mg.m-3

Subchronic TRV

Inhalation route

4,3 mg.m-3

Chronic TRV

Inhalation route

1,5 mg.m-3

Formaldehyde

(CAS 50-00-0)

2017

Acute TRV

Inhalation route

123 µg.m-3

Chronic TRV

Inhalation route

123 µg.m-3

Lead

(CAS 7439-92-1)

2012

Blood lead level

15 µg.L-1

Linuron

(CAS 330-55-2)

2008

Subchronic TRV

Oral route

0,05 mg.kg-1.d-1

 

Methyl methacrylate

(CAS 80-62-6)

 

2017

Chronic TRV

Inhalation route

0,7 mg.m-3

Microcystin-LR

(CAS 101043-37-02)

2019

Subchronic TRV

Oral route

1 ng.kg-1.d-1

n-butyl acetate

(CAS 123-86-4)

2017

Chronic TRV

Inhalation route

2 mg.m-3

N-hexane

(CAS 110-54-3)

2013

Chronic TRV

Inhalation route

3 mg.m-3

m-nitrochlorobenzene

(CAS 121-73-3)

2009

Carcinogen TRV

Inhalation and oral route

No TRV

N-nitrosomorpholine

(CAS 59-89-2)

2012

Carcinogen TRV

Oral route

4 (mg.kg p.c.-1.d-1)-1

Naphthalene

(CAS 91-20-3)

2013

Chronic TRV

Inhalation route

37 µg.m-3

Carcinogen TRV

 

Inhalation route

5,6.10-3 (mg.m-3)-1

o- nitrochlorobenzene

(CAS 88-73-3)

2009

Chronic route

Oral route

80 µg.kg-1.d-1

2009

Carcinogen TRV

Oral route

6.10-5 (µg.kg-1.d-1)-1

p-nitrochlorobenzene

(CAS 100-00-5)

2009

Chronic TRV

Oral route

34 µg.kg-1.d-1

2009

Carcinogen TRV

Oral route

5.10-5 (µg.kg-1.d-1)-1

Nonylphenol - branched

(CAS 90481-04-2 84852-15-3)

2009

Subchronic TRV

Oral route

0,03 mg.kg-1.d-1

Nonylphenol - linear

(CAS 25154-52-3 / 104-40-5)

2009

Subchronic TRV

Oral route

0,03 mg.kg-1.d-1

Octamethylcyclotetrasiloxane

(CAS S 556-67-2)

2017

Chronic TRV

Inhalation route

183 mg.m-3

Perchloroethylene

(CAS 127-18-4)

2018

Acute TRV

Inhalation route

1,38 mg.m-3

Subchronic TRV

Inhalation route

0,4 mg.m-3

Chronic TRV

Inhalation route

0,4 mg.m-3

Carcinogen TRV

Inhalation route

2,6.10-7 (µg.m-3)-1

 

Perfluorobutanesulfonic acid

(CAS 375-73-5)

2017

Chronic TRV

Oral route

0,08 mg.kg-1.d-1

Perfluorohexanoic acid

(CAS 307-24-4)

2017

Chronic TRV

Oral route

0,32 mg.kg-1.d-1

Saxitoxin

(CAS 35523-89-8)

2020

Acute TRV

Oral route

0,1 µg.kg-1.j-1

Sec butyl éther

(CAS 6863-58-7)

2015

No TRV

Tert-butanol (TBA)

(CAS 75-65-0)

2015

TRV toxic to reproduction

Oral route

1,9 mg.kg pc-1.d-1

2015

Chronic TRV

Oral route

0,6 mg.kg pc-1.d-1

2015

Chronic TRV

Inhalation route

2,1 mg.m-3

Titanium dioxide

under nanoform (P25)

 (CAS 13463-67-7)

2019

Chronic TRV

Inhalation

0,12 µg.m-3

Trichloroacetic acid

(CAS 76-03-9)

2009

Acute TRV

Oral route

300 µg.kg-1.d-1

Trichloroethylene

(CAS 79-01-6)

2018

 

Acute TRV

Inhalation route

No TRV
2018

 

Subchronic TRV

Inhalation route

3,2mg.m-3
2018

 

Chronic TRV

Inhalation route

3,2 mg.m-3
2018

Carcinogen TRV

Inhalation route

10-6 (µg.m-3)-1

Toluene

(CAS 108-88-3)

2017

 

Acute TRV

Inhalation route

21 mg.m-3

Chronic TRV

Inhalation route

19 mg.m-3

Vinyl chloride

(CAS 75-01-4)

2012

Carcinogen TRV

Oral route

0,625 (mg.kg-1.d-1)-1

2012

Carcinogen TRV

Inhalation route

0,0038 (mg.m-3)-1

Xylènes

(xylène technique CAS n°1330-20-7

méta-xylène CAS n°108-38-3

ortho-xylène CAS n°95-47-6

para-xylène CAS n°106-42-3)

2020

Acute TRV

Inhalation route

8,7 mg.m-3
2020

Chronic TRV

Inhalation route

0,1 mg.m-3
 Update date : November 2020