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anses

French Agency for Food, Environmental and Occupational Health & Safety

List of toxicity reference values (TRVs) established by ANSES

The Agency entrusted TRV validation to the Expert Committee (CES) on "Health reference values ". Accordingly, toxicity reference values have already been established  for the following substances.

 

Chemical

Year

Sort of TRV

TRV

1,2 dichloroethane

(CAS 107-06-2)

2009

Carcinogen TRV

Inhalation route 

 

3,4.10-3 (mg.m-3)-1

 

2-chloroaniline

(CAS 95-51-2)

2018

Acute TRV

Oral route

73µg.kg p.c.-1.d-1
2018

Acute TRV

Inhalation route

256 µg.m-3
2018

Subchronic TRV

Oral route

16 µg.kg p.c.-1.d-1

2018

Subchronic TRV

Inhalation route

55µg.m-3
2018

Chronic TRV

Oral route

5 µg.kg p.c.-1.d-1
2018

Chronic TRV

Inhalation route

18µg.m-3

3-chloroaniline

(CAS 108-42-9)

2018

Acute TRV

Oral route

11 µg.kg p.c.-1.d-1
2018

Acute TRV

Inhalation route

39 µg.m-3
2018

Subchronic TRV

Oral route

5 µg.kg p.c.-1.d-1
2018

Subchronic TRV

Inhalation route

18 µg.m-3
2018

Chronic TRV

Oral route

1 µg.kg p.c.-1.d-1
2018

Chronic TRV

Inhalation route

4µg.m-3

4-chloroaniline

(CAS 106-47-8)

2018

Subchronic TRV

Oral route

5 µg.kg p.c.-1.d-1
2018

Subchronic TRV

Inhalation route

18µg.m-3
2018

Chronic TRV

Oral route

1 µg.kg p.c.-1.d-1
2018

Chronic TRV

Inhalation route

µg.m-3

4-Vinyl-1-cyclohexene

(CAS 100-40-3)

2015

Chronic TRV

Oral route

0,32 mg .kg.pc-1.d-1
2015

Chronic TRV

Inhalation route

2,7 mg.m-3
2015

Carcinogen TRV

Oral route

1,3.10-5 (µg.kg p.c.-1.d-1)-1
2015

Carcinogen TRV

Inhalation route

3,8.10-6 (µg.m-3)-1

Ethyl acetate

(CAS 141-78-9)

2015

Chronic TRV

Inhalation route

6,4 mg.m-3

n-butyl acetate

(CAS 123-86-4)

2017

Chronic TRV

Inhalation route

2 mg.m-3

Dibromoacetic acid

(CAS 631-64-1)

2010

Chronic TRV

Oral route

30 µg.kg-1.d-1

Dichloroacetic acid

(CAS 79-43-6)

2009

Acute TRV

Oral route

260 µg.kg-1.d-1

Chronic TRV

Oral route

840 µg.kg-1.d-1

Perfluorobutanesulfonic acid

(CAS 375-73-5)

2017

Chronic TRV

Oral route

0,08 mg.kg-1.d-1

Perfluorohexanoic acid

(CAS 307-24-4)

2017

Chronic TRV

Oral route

0,32 mg.kg-1.d-1

Trichloroacetic acid

(CAS 76-03-9)

2009

Acute TRV

Oral route

300 µg.kg-1.d-1

Acrolein

(CAS 107-02-8)

2019

Acute TRV

Inhalation route

6,9 µg.m-3

Subchronic TRV

Inhalation route

0,44 µg.m-3

Chronic TRV

Inhalation route

0,15 µg.m-3

Ammonia

(CAS 7664-41-7)

2017

Acute TRV

Inhalation route

5,9 mg.m-3

Subchronic TRV

Inhalation route

0,5 mg.m-3

Chronic TRV

Inhalation route

0,5 mg.m-3

Benzene

(CAS 71-43-2)

2013

Carcinogen TRV

Inhalation route

2,6.10-5 (µg.m-3)-1

Butyl benzyl phthalate (BBP)

(CAS 85-68-7)

2008

Subchronic TRV

Oral route

0,5 mg.kg-1.d-1

Cadmium and cadmium compounds

(CAS 7440-43-9, 10108-6-2,

1306-19-0, 10124-36-4,

1306-23-6, 10325-94-7)

2017

Chronic TRV

Oral route

0,35 µg.kg-1.d-1

2012

Chronic TRV 

Inhalation route 

 

0,45 µg.m-3

2012

Carcinogen TRV

Inhalation route

 

0,3 µg.m-3

Chloroform

(CAS 67-66-3)

2008

Chronic TRV

Inhalation route

63 µg.m-3

m-nitrochlorobenzene

(CAS 121-73-3)

2009

Carcinogen TRV

Inhalation and oral route

No TRV

o- nitrochlorobenzene

(CAS 88-73-3)

2009

Chronic route

Oral route

80 µg.kg-1.d-1

2009

Carcinogen TRV

Oral route

6.10-5 (µg.kg-1.d-1)-1

p-nitrochlorobenzene

(CAS 100-00-5)

2009

Chronic TRV

Oral route

34 µg.kg-1.d-1

2009

Carcinogen TRV

Oral route

5.10-5 (µg.kg-1.d-1)-1

Vinyl chloride

(CAS 75-01-4)

2012

Carcinogen TRV

Oral route

0,625 (mg.kg-1.d-1)-1

2012

Carcinogen TRV

Inhalation route

0,0038 (mg.m-3)-1

Cylindrospermopsin

(CAS 143 545-90-8)

2019

Subchronic TRV

Oral route

0,14 µg.kg-1.d-1

Dibutyl phthalate (DBP)

(CAS 84-74-2)

2008

Subchronic TRV

Oral route

0,002 mg.kg-1.d-1

Decamethylcyclopentasiloxane

(D5)

(CAS 541-02-6)

2017

Chronic TRV

6,4 mg.m-3

 Diisobutylene (DIB)

(CAS 25167-70-8)

2015

Chronic TRV

Oral route

0,8 mg.kg pc-1.d-1

2015

Chronic TRV

Inhalation route

3 mg.m-3

Diisopropyl ether (DIPE)

(CAS 108-20-3)

 

2015

Chronic TRV

Oral route

4 mg.kg pc-1.d-1

2015

Chronic TRV

Inhalation route

14,5 mg.m-3

2015

Developmental TRV

Oral route

2 mg.kg pc-1.d-1

2015

Developmental TRV

Inhalation

7,2 mg.m-3

2015

Carcinogen TRV

Oral route

7,8.10-6 (µg.kg p.c.-1.d-1)-1

2015

Carcinogen TRV

Inhalation route

2,2.10-6 (µg.m-3)-1

Titanium dioxide

under nanoform (P25)

 (CAS 13463-67-7)

2019

Chronic TRV

Inhalation

0,12 µg.m-3

2-ethoxyethanol

(CAS 110-80-5)

2009

Chronic TRV

Inhalation route

0,07 mg.m-3

Ethylbenzene

(CAS 100-41-1)

2016

Acute TRV

Inhalation route

22 mg.m-3

2016

Subchronic TRV

Inhalation route

4,3 mg.m-3

2016

Chronic TRV

Inhalation route

1,5 mg.m-3

Formaldéhyde

(CAS 50-00-0)

2017

Acute TRV

Inhalation route

123 µg.m-3

Chronic TRV

Inhalation route

123 µg.m-3

Chloral hydrate

(CAS 302-17-0)

2010

Chronic TRV

Oral route

28 µg.kg-1.d-1

Linuron

(CAS 330-55-2)

2008

Subchronic TRV

Oral route

0,05 mg.kg-1.d-1

 

Methyl methacrylate

(CAS 80-62-6)

 

2017

Chronic TRV

Inhalation route

0,7 mg.m-3

Microcystin-LR

(CAS 101043-37-02)

2019

Subchronic TRV

Oral route

1 ng.kg-1.d-1

N-hexane

(CAS 110-54-3)

2013

Chronic TRV

Inhalation route

3 mg.m-3

N-nitrosomorpholine

(CAS 59-89-2)

2012

Carcinogen TRV

Oral route

4 (mg.kg p.c.-1.d-1)-1

Naphthalene

(CAS 91-20-3)

2013

Chronic TRV

Inhalation route

37 µg.m-3

Carcinogen TRV

 

Inhalation route

5,6.10-3 (mg.m-3)-1

Linear nonylphenol

(CAS 25154-52-3 / 104-40-5)

2009

Subchronic TRV

Oral route

0,03 mg.kg-1.d-1

Branched nonylphenol

(CAS 90481-04-2 84852-15-3)

2009

Subchronic TRV

Oral route

0,03 mg.kg-1.d-1

Octamethylcyclotetrasiloxane

(CAS S 556-67-2)

2017

Chronic TRV

Inhalation route

183 mg.m-3

Perchloroethylene

(CAS 127-18-4)

2018

Acute TRV

Inhalation route

1,38 mg.m-3

Subchronic TRV

Inhalation route

0,4 mg.m-3

Chronic TRV

Inhalation route

0,4 mg.m-3

Carcinogen TRV

Inhalation route

2,6.10-7 (µg.m-3)-1

 

bis(2-ethylhexyl) phthalate (DEHP)

(CAS 117-81-7)

2012

Chronic TRV

Oral route

0,05 mg.kg-1.d-1

Ddi-n-octyl phthalate (DnOP)

(CAS 117-84-0)

2017

 

No TRV

Diisobutyl phthalate (DIBP)

(CAS 84-69-5)

2017

Acute TRV (reprotoxic)

Oral route

0,002 mg.kg-1.d-1

Diisooctyl phthalate (DIOP)

(CAS 27554-26-3)

2017

Acute TRV (reprotoxic)

Oral route

0,004 mg.kg-1.d-1

Dimethyl phthalate

(CAS 131-22-3)

2015

 

No TRV

Lead

(CAS 7439-92-1)

2012

Blood lead level

15 µg.L-1

Sec butyl éther

(CAS 6863-58-7)

2015

No TRV

Tert-butanol (TBA)

(CAS 75-65-0)

2015

TRV toxic to reproduction

Oral route

1,9 mg.kg pc-1.d-1

2015

Chronic TRV

Oral route

0,6 mg.kg pc-1.d-1

2015

Chronic TRV

Inhalation route

2,1 mg.m-3

Trichloroéthylène

(CAS 79-01-6)

2018

 

Acute TRV

Inhalation route

No TRV
2018

 

Subchronic TRV

Inhalation route

3,2mg.m-3
2018

 

Chronic TRV

Inhalation route

3,2 mg.m-3
2018

Carcinogen TRV

Inhalation route

10-6 (µg.m-3)-1

Carbon tetrachloride

(CAS 56-23-5)

2017

Carcinogen TRV

Inhalation route

0,11 mg.m-3

Toluene

(CAS 108-88-3)

2017

 

Acute TRV

Inhalation route

21 mg.m-3

Chronic TRV

Inhalation route

19 mg.m-3

 Update date : February 2020