Chemical substances, singly or combined in mixtures, may have various harmful effects on human health. Some of them may be carcinogenic, mutagenic or reprotoxic. In this case they are categorised as “CMRs”. In view of the hazards they present, these classified substances and mixtures are subject to restrictive regulations, particularly in the workplace. Preventing the risks associated with CMRs in the workplace is primarily based on replacing the hazardous product with another that is not hazardous or is less harmful (substitution).Discover the role the Agency plays in this process.