Environmental health

As part of its missions and under the French National Environmental & Health Action Plan (2004-2008), the Agency began a national programme on TRVs in 2004 with the aim of building solid French expertise that could be shared by the various competent authorities in this area.

As they disperse in our environment, pesticides can be transformed into one or more other compounds called "metabolites". The active substances of pesticides and their metabolites are therefore liable to contaminate water resources and end up in drinking water (DW). ANSES supports the authorities in managing situations where the regulatory limits are exceeded, in order to guarantee consumer health. It has also designed a method for identifying which pesticide metabolites warrant priority attention, with regard to the health issues associated with drinking water consumption.

What is formaldehyde? Formaldehyde is a chemical compound occurring at room temperature as a colourless and flammable gas. It is often marketed in its liquid form, commonly known as formalin. How does exposure to formaldehyde occur? Formaldehyde is used in many occupational sectors and consumer products. It is a biocidal product used as a disinfectant, fixative and preservative. It is found in DIY and cleaning products, in wall coverings, flooring and furniture panelling and fabrics, plastics and other products. In the general population, exposure can occur through a wide range of formaldehyde sources in indoor air, including from fixtures and fittings, and decorating and household products that release formaldehyde. Formaldehyde is also released by combustion of cigarettes and tobacco products, candles, incense sticks and in open fireplaces and combustion appliances such as gas cookers and paraffin stoves. According to the findings of the 2017 SUMER survey, more than 185,000 workers were exposed to formaldehyde (PDF) (in French) (not counting exposure through formaldehyde-based resins and adhesives). The greatest exposure is in the health sector and in anatomical and cytological pathology laboratories (anatomical pathologists), the funeral industry (embalmers), agriculture, the chemical, food, paper and board, timber and furniture industries and in construction. What are the effects on health? The critical effects of acute or chronic formaldehyde exposure in humans are irritation of the eyes and respiratory tract. Airborne formaldehyde also causes nasopharyngeal cancer in humans, as observed in epidemiological studies of workers exposed to high levels of formaldehyde. How is formaldehyde regulated? Key formaldehyde dates: 2004 : The International Agency for Research on Cancer (IARC) classified formaldehyde as a “carcinogenic to humans” (Group 1) for nasopharyngeal cancer by inhalation. 2006 : The French Ministry of Labour included “work involving exposure to formaldehyde” on the list of carcinogenic substances, preparations and processes, as defined by the Labour Code, in an Order dated July 2006. This became effective on 1 January 2007 and requires the implementation of formaldehyde substitution measures as a priority. 2009 : Nasopharyngeal cancer was recognised as an occupational disease (Table 43 bis on cancerous conditions caused by formaldehyde) when linked to exposure in the workplace for 5 years through tasks such as formalin preparation, formaldehyde use in embalming and anatomical and cytological pathology laboratories, manufacture and use of formaldehyde-based resins and wood flooring varnishes, and fire extinguishing. 2014 : Following ANSES’s classification proposal , formaldehyde was classified as a Category 1B carcinogen and Category 2 mutagen at European level by Commission Regulation (EU) No 605/2014 of 5 June 2014. 2019 : A binding occupational exposure limit was adopted at European level (Directive 2019/983/EC), which was then transposed into French law by Decree No 2020-1546 of 9 December 2020. 2020 : Following an evaluation by the German Government, formaldehyde was approved as a biocidal active substance for product types 2 and 3 for a reduced period of 3 years. Companies marketing disinfectant biocidal products containing formaldehyde were required to apply for a marketing authorisation before 1 February 2022, with supporting arguments demonstrating that the products do not cause human or environmental exposure and why they are essential. What does ANSES’s work on the risks associated with formaldehyde use include? For more than ten years, ANSES has been conducting various expert assessments to evaluate the toxicity of formaldehyde, qualify and reduce human exposure, particularly in the workplace, and evaluate health risks. Assessing the risks for people (general population and workers) After formaldehyde was classified by the IARC in June 2004, the Agency was asked to assess the health risks associated with formaldehyde in indoor, outdoor (PDF) (in French) and occupational environments (PDF) (in French) . The main conclusions of two expert appraisal reports published by ANSES in 2008 were as follows: ranking sources of formaldehyde in indoor environments and evaluating their respective contributions to the exposure of the general population is challenging; the risk of cancer in the general population can be ruled out for both adults and children; the risk of nasopharyngeal cancer in workers cannot be ruled out in a number of occupational sectors with repeated high levels of exposure; the formaldehyde content of products intended for the general public should be reduced, and such products should be labelled with their formaldehyde emission levels. Reducing formaldehyde emissions at source In 2006 and 2009, ANSES proposed a protocol to identify and promote “low-emitting” building materials and decorating products among consumers. This work has been useful for developing French legislation on the labelling of these materials. In 2014, ANSES worked on priority chemicals to support the government in implementing future labelling requirements for volatile contaminants from furniture products (PDF) (in French) . Formaldehyde was identified as one of these priority chemicals for labelling. Regulating the use of formaldehyde In 2011, ANSES drafted and submitted a proposal on behalf of the French Government for a stricter classification of formaldehyde at European level. On the basis of this proposal, formaldehyde was classified as a category 1B carcinogen and a category 2 mutagen. In 2013, ANSES and the RIVM (National Institute for Public Health and the Environment of the Netherlands) jointly took charge of the assessment of formaldehyde under the REACH Regulation. Following this review of occupational risks (PDF) (in French) , ANSES identified health risks for workers in several occupational sectors and recommended the implementation of a risk reduction strategy. In 2017, ANSES examined different options for regulatory control of formaldehyde (PDF) (in French) in order to reduce and manage the risks for workers, and recommended the establishment of a binding occupational exposure limit at European level. Establishing health reference values The Agency develops health reference values for the general population and workers based on toxicity data. These reference values are based on health criteria and aim to protect people from any adverse effects due to exposure to chemicals. In 2017, in the light of new published data, it updated the reference values for formaldehyde, the earliest of which dated from 2007: acute and chronic toxicity reference values (TRVs) by inhalation were set at 123 µg.m-3. TRVs are toxicological indicators used to qualify or quantify the risk to human health associated with exposure to a chemical. They are used by companies and research institutions to demonstrate risk management and by government to establish recommendations on risk management; the indoor air quality guideline (IAQG) was set at 100 µg.m-3 to align it with WHO’s 2010 indoor air guideline. ANSES’s recommended IAQGs are airborne chemical concentration thresholds under which no health impacts or harm are expected in the general population; occupational exposure limits (OELs) were aligned with values set by the 2019 European Directive: an 8h-OEL of 350 µg.m-3 and a 15min-STEL of 700 µg.m-3. ANSES’s recommended OELs are usually airborne chemical concentration levels that workers can breathe during a specified period without experiencing adverse health effects. The concentration levels are determined for a homogeneous exposed population (workers) that excludes children and the elderly. Reducing health risks in the workplace Beyond recommending occupational exposure limits for formaldehyde, which will limit exposure levels in the workplace once introduced at the regulatory level, ANSES received a request from the government in 2014 for guidance on the potential substitution of formaldehyde in five occupational sectors : the feed industry (PDF) (in French) , mainly for formaldehyde treatment of soybean cakes; anatomical and cytological pathology (PDF) (in French) in medical diagnostics; embalming (PDF) (in French) ; the food industry, particularly the manufacture of sugar (PDF) (in French) and alginates (PDF) (in French) ; fish farming (PDF) (in French) . To carry out this work, the Agency developed an overall method for comparing a chemical to its alternatives. Expert appraisals in occupational diseases ANSES is currently conducting expert appraisals on the links between occupational exposure to formaldehyde and leukaemia, including myeloid leukaemia. This work will provide the scientific information needed for discussing any changes to the existing occupational disease tables or recommending new tables.

Working at the interface between human and animal health, in the spirit of "One Health", ANSES's laboratories help provide effective, rapid responses to issues of applied research that can be implemented immediately. As an example, since the start of the COVID-19 pandemic, ANSES has been deploying its research teams, its expert knowledge of zoonoses and animal coronaviruses, and its network of laboratories to improve our understanding of SARS-CoV-2 and respond to questions that have arisen from this crisis. Here is an overview of the various projects undertaken by the Agency.

ANSES calls for continued vigilance to avoid accidents when using disinfectant products for swimming pools and spas. The Agency recommends strictly observing the instructions for use and safety precautions, only handling the products outdoors or otherwise in a well-ventilated room, not mixing them together in the same container and storing them away from humidity and heat. These products must also be kept out of the reach of children.

Milk, meat, vegetables... any of the food we eat can be a source of contamination. Through the transmission of bacteria, parasites, viruses of animal or plant origin, or chemical contaminants, our food can potentially cause illness or poisoning in humans. Food safety forms part of a global "one health" approach, at the interface of animal, plant and human health. To protect consumers from the risks of food contamination and prevent potential outbreaks, it is essential to take action at all stages of the food chain, "from farm to fork". This is ANSES's role.

Lyme disease, Zika, chikungunya, dengue... Recent years have seen a re-emergence of the pathogens responsible for these diseases, which are transmitted by insects and other arthropods. On Thursday 17 December 2020, ANSES is hosting a scientific webinar on the new prospects for controlling these species, known as vectors. The Agency is taking this opportunity to explain exactly what these pathogen vectors are: not only tiger mosquitoes and ticks, but other vectors of diseases specifically affecting animals or plants. What is ANSES doing in the areas of expert appraisal and research to address these health issues? All the answers are in this dossier on the subject.

Some arthropods (a family that includes insects and arachnids) such as ticks and mosquitoes can transmit pathogens that cause diseases in animals, plants and/or humans. Several ANSES laboratories are studying vector-borne diseases transmitted to animals and the ability of vectors to transmit these pathogens.

The "One Health" concept was first put forward in the early 2000s, with growing awareness of the close links between human health, animal health and the overall state of the environment. It aims to promote a multidisciplinary, global approach to health issues. ANSES's work is fully in line with the One Health concept, and the Agency is coordinating several projects based on it.

Since their introduction in France in 2007, the use of vaping products has spread very quickly, and the national market continues to expand. What are these new products, how are they regulated and what risks can they pose to our health? Update on ANSES’s work

Under the regulations on tobacco and related products, ANSES is responsible for collecting and analysing the information reported by manufacturers on the products sold in France. As part of this work, the Agency is providing expert scientific support to the Directorate General for Health (DGS). It provides knowledge on the products placed on the French market, along with scientific intelligence on product composition. The Agency also conducts expert appraisals to assess the health risks associated with these products, which ties in with its other work on chemicals in consumer products and the health risks related to air quality. Overview of ANSES's responsibilities

Alcohol-based gels and solutions used as hand sanitisers are disinfectants designed to remove bacteria or viruses from healthy skin. They are biocidal products, and as such are subject to the European Regulation on these products. ANSES is responsible for assessing and issuing marketing authorisations for these types of products. Following their massive use in response to the COVID-19 pandemic, the Agency issued an opinion on the effectiveness criteria for hand sanitisers. What properties make them effective against viruses or bacteria? Can they replace hand washing? How should they be stored?