Antimicrobial resistance
The French agency for veterinary medicinal products (ANMV), within ANSES, relies on two tools for monitoring antimicrobial uses in veterinary medicine:
- the national monitoring of sales of veterinary medicinal products containing antimicrobials, which has been in place since 1999 and allows the annual collection of sales volumes from marketing authorisation holders (MAHs),
- the national monitoring of antimicrobial use based on mandatory reporting of all antimicrobial cessions by veterinarians, pharmacists, manufacturers and distributors of medicated feed via the CalypsoVet platform.
These two follow-ups are complementary and make it possible to assess the use of antimicrobials and to monitor the evolution of antibiotic therapy practices for the different animal species. The information collected is one of the essential elements, together with the bacterial resistance monitoring systems, to enable an assessment of the risks associated with antibiotic resistance.
In addition, the ANMV analyses the risks associated with antimicrobial resistance in the context of marketing authorisation procedures. The Agency is also working on the evaluation of risky practices in veterinary medicine and on possible alternatives to the use of antibiotics on farms.
Finally, ANMV is involved in national, European and international reflections on the collection of data on sales and uses of antimicrobials, on the One Health risk assessment for antimicrobial resistance and on integrated surveillance allowing the analysis of the links between uses and resistance to antibiotics.
The different areas of activity of the ANMV antibiotic resistance department:
- Monitoring of sales of antimicrobial medicines by MAHs
- Transmission of antibiotic sales data to the European Medicines Agency (EMA) and the World Organisation for Animal Health (WOAH)
- Monitoring antimicrobial use via CalypsoVet
- Monitoring antibiotic use on the farm
- Participation in the assessment of national and European dossiers for marketing authorisations for veterinary medicinal products containing an antimicrobial.
- Involvement in the drafting of scientific opinions and participation in referrals on antimicrobials and antimicrobial resistance.
- Participation in the steering committee of the Ecoantibio plan led by the Directorate-General for Food (DGAl) of the Ministry in charge of Agriculture.
- Contribution to the issues related to resistance risks and integrated surveillance by participating in the development of the Inter-ministerial Roadmap 2024-2034 "Prevention and reduction of antimicrobial resistance, fight against antimicrobial resistance"
- Participation in the AWP (Antimicrobials Working Party), EMA Working Party on issues relating to the use and authorisation of antimicrobials, in scientific support to the Committee for Veterinary Medicinal Products (CVMP) on issues relating to the authorisation of antimicrobials, their use and antimicrobial resistance.
- Participation in the ADRA WP (Antibiotic Dose Review and Adjustment Working Party), EMA working group in scientific support to the CVMP on issues related to the revision of dosages of veterinary antibiotic medicinal products.
- Contribution to the work of AMEG (Antimicrobial Advice Ad Hoc Expert Group), which produces opinions on requests from the European Commission (colistin, European categorisation of antibiotics).
- Participation in the ESUAvet (European Sales and Use of Antimicrobials for Veterinary Medicine Working Group) and in the establishment of harmonised collection of sales and use data for antimicrobial medicinal products in the framework of European regulations.
- Participation in JIACRA, an inter-agency group composed of the European Centre for Disease Prevention and Control (ECDC), the European Food Safety Authority (EFSA) and the EMA, leading expert work for the European Commission, in particular on the link between consumption and antibiotic resistance in both veterinary and human medicine.
- As a collaborating centre of the World Organisation for Animal Health (WOAH), participation in the work of the WOAH on antimicrobials and antimicrobial resistance.
- Participation in One Health international work and reflections on resistance risk assessment and integrated surveillance.